2021 edition, adopted by the World Conference in Katowice on 7 November 2019 and in force from 1 January 2021.
| Adoption | 7 November 2019 — WADA Executive Committee, Katowice Conference |
| In force from | 1 January 2021 |
| Structure | International Standard for Therapeutic Use Exemptions, 2021 edition |
| Status | Superseded — replaced by the 2023 edition |
The International Standard for Therapeutic Use Exemptions (ISTUE) is one of the mandatory International Standards of the world anti-doping system. The International Standards set out the technical detail of implementing the Code, and compliance with them is mandatory for all Signatories to the Code. This Standard determines the conditions under which, and the procedure by which, an athlete who must use a prohibited substance or method because of a medical condition obtains a Therapeutic Use Exemption, who decides on the application, and in which cases the decision is subject to review and appeal.
The most frequently used Standard for team physicians and athletes. The four conditions for granting an exemption, the deadline for submitting an application, the possibility of applying with retroactive effect, and the deciding and appeal bodies are all set out in this text; and in doping cases, the existence or absence of a valid exemption is the first thing examined.
Each case is governed by the version of this Standard that was in force at the time of the events; for that reason, earlier versions are kept available on this page. The official text is published in English and French and, in the event of any conflict, the English text prevails.